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CORE COURSES


M.Tech (2-year) Course Curriculumnew

Minor in BMEnew

BM 5030 Scientific Computing and data analysis

The course intends to introduce the students of first year interdisciplinary masters programs to scientific computing and tools for the same. This course will be compulsory for students with basic degree in Life sciences and others not exposed to quantitative sciences. The main contents of the course are : Matrices, matrix operations, factorisations, eigen values, transforms, Linear equations; Coding in MATLAB and Python using matrices as elementary structures; Probability and random variables;statistical hypothesis testing.
References
1. Strang, Gilbert. Introduction to Linear Algebra, Wellesley Cambridge Press.

BM 6150 Mathematical Physiology and Modeling

This course for senior undergraduates and postgraduates will introduce the principles of physiology and its mathematical characterisation. The course will cover the important elements of physiology like Cellular function, Growth, Homoeostasis and metab , Characterisation of some systems e.g. Cardiovascular, Respiratory, Endocrine
References
1. Herman, Irving P. Physics of the human body. Springer Science & Business Media, 2007.
2. Dee Unglaub Silverthorn, Human Physiology : An integrated approach,  Pearson.
3. Michael C. K. Khoo, Physiological Control Systems: Analysis, Simulation, and Estimation,IEEE Press series.

BM 5050 Introduction to Brain and Neuroscience

This course is an undergraduate's introduction to the fascinating world of the brain and its study. The course will give an overview of the structure and function of the brain along with the nervous system using interesting case studies and descriptions of experiments. Students will be introduced to various disciplines that go under the umbrella term of neurosciences like Cognitive, behavioral, network, cellular, developmental or computational neurosciences. The course will emphasize on the interdisciplinary nature of modern neuroscience and opportunities for people from various backgrounds to contribute to it. Towards the end of the course students pick a landmark paper or case study and present the same in class.

Syllabus :- Introduction - Organization of the brain and its function; Behaviour and cognition; Systems : Motor, sensory and learning; Regions; Networks; Neuron; Ion channels; Neural development and disease; Role of experiments and computation in neuroscience; Methods in neuroscience; The interdisciplinary nature of neuroscience

References
1. Neuroscience, Purves et al, Sinauer Associates Inc, (2010).

BM 6140 Theoretical and Computational Neuroscience: From cell to systems

This course is a first pass through the principles of working of the brain from the level of a single neuron to systems and behaviour. The course focuses on characterising the operating principles of the brain at various levels and the mathematical models used to represent them. The objective of the course is to develop in students an ability to convert concepts in neurophysiology into a mathematical model.

Syllabus :- Genesis of electrical activity in cells, resting membrane potentials; Neuron equivalent circuits and passive propagation in neurons; Hodgkin-Huxley equations and conductance based models; Ion channels and their diversity; Simple neuron models and analysis using dynamical systems concepts; Chemical and electrical synapses and their models; Neuronal networks and techniques for mathematical analysis; Models of learning and memory in the neuron and the network; Models of cognition, decision making and psychophysical models; Systems (sensory and motor systems) and their modeling; Neural coding (Rate, temporal, population); Neuronal data analysis techniques (Pre-processing, Spike detection and sorting techniques).

References        
1. Foundations of Cellular Neurophysiology, Johnston and Wu, (2011).
2. Mathematical foundations of Neuroscience, Ermentrout and Terman (2012).

BM 5060  Cellular Physiology

This course is intended for basic understanding of cell physiology in the engineers’ perspective. The students need to understand the cellular structure and physiological functions.

Syllabus :- Cell structure and its organelles; Cell membrane; Cell homeostasis; Nucleus structure and function of its different components.
References        
1. Ganong's Review of Medical Physiology. Kim E. Barrett, Heddwen Brooks, Scott Boitano, Susan M. Barman. McGraw-Hill Education, 24th edition.
2. Guyton and Hall Textbook of Medical Physiology, by John E. Hall, 12th Edition.

BM 5070   Systems Physiology

This course is intended for basic understanding of human physiology in the engineers’ perspective. The students need to understand different physiological systems; and their dysfunction by applying engineering and mathematics knowledge. The important systems which may be covered are respiratory, renal, endocrine, gastro-intestinal tract, cutaneous, and other relvant systems.

Syllabus :- Respiratory: anatomy, gas exchange, acid-base balance; Renal: anatomy, ion exchange, transport of metabolites; Gastro-intestinal tract: anatomy, absorption of micro-nutrients, dysfunction; Cutaneous system: anatomy, temperature regulation; Endocrine: basic function, major endocrine organs and their regulation, bone physiology;
References        
1. Ganong's Review of Medical Physiology. Kim E. Barrett, Heddwen Brooks, Scott Boitano, Susan M. Barman. McGraw-Hill Education, 24th edition.
2. Guyton and Hall Textbook of Medical Physiology, by John E. Hall, 12th Edition.

BM 6023   Cell technology

This course is intended for practical handling experience for students for culture of mammalian cells. They should learn detailed step-wise protocols in culturing, freezing, splitting of mammalian cells. They should also learn basic molecular biology methods such as DNA, RNA isolation from cultured cells and running a polymerase chain reaction.
Syllabus :- Cell culture, splitting; Cell freezing and thawing; Identification of cells in blood smear; DNA, RNA isolation; PCR reaction.
References
1. Culture of animal cells. Editor: R. Ian Freshney. 6th edition.

BM 6120   Tissue Engineering

The students will learn how to test the biomaterials along with a number of cell types in vitro and in vivo. He should learn how the physiological cues are combined together with biomaterials for regenerative medicine point of view.

Syllabus :- Tissue engineering: fundamentals and current status; Stem cells: embryonic and mesenchymal stem cells; cell differentiation; Extra-cellular matrix components and their regulation of cell behavior; In vitro and in vivo testing of biomaterials. Bioreactor; Cell migration; Growth factors; Different approaches for angiogenesis and its importance.
References
1. Tissue Engineering: by Clemens Van Blitterswijk, Jan De Boer, Clemens van Blitterswijk, Peter Thomsen, Jeffrey Hubbell, Ranieri Cancedda, J.D. de Bruijn, Anders Lindahl, Jerome Sohier, David F. Williams. Academic press.
2. Principles of Tissue Engineering. Robert Lanza, Robert Langer, Joseph P. Vacanti. Academic press.

BM 6126   Regenerative Medicine

The students will learn in a seminar-based manner about a number of tissue-specific regenerative medicine and various approaches to achieve this.
Syllabus :- Tissue-specific regenerative medicine: Bone, cartilage. Regulation and ethics of tissue engineering; Advanced methods applied in regenerative medicine field.
References      
1. Tissue Engineering: by Clemens Van Blitterswijk, Jan De Boer, Clemens van Blitterswijk, Peter Thomsen, Jeffrey Hubbell, Ranieri Cancedda, J.D. de Bruijn, Anders Lindahl, Jerome Sohier, David F. Williams. Academic press.
2. Principles of Tissue Engineering. Robert Lanza, Robert Langer, Joseph P. Vacanti. Academic press.

BM 5013   Sensors and Transducers in Health care

This course is intended to understand the origin of signals in biosystems and living organisms, their sensing, detection and meaningful processing for practical diagnostic sensing applications.  Various engineering aspects of the detection, acquisition, processing, and display of signals, biomedical sensors for measurements of biopotentials, ECG, force, displacement, blood pressure and temperature sensors, will be addressed in this course. The course includes work involving circuits, electronics, sensor design and interfaces for building complete biomedical instrumentation.

Syllabus :-
Displacement sensors: Resistive sensors, strain sensors, bridge circuits, Inductive, capacitive, piezo-electric sensors; Temperature sensors: thermoelectric, radiation thermometry, thermistors, fiber-optic sensors; Biopotentials: Origin of biopotentials, Cell, nerve and muscle protentials, Action potential, resting potential, Membrane structure and Nernst Equation, Nerve cell, Biopotential electrodes and biopotential amplifiers, ECG principle, sensing, 12-Lead ECG PQRS characteristics.
References        
1. Medical Instrumentation Application and Design, John Webster Ed. John Wiley & Sons 2009.
2. Operational Amplifiers and linear ICs,R. A. Gayakwad, Phi Learning, 2009.
3. Additional research papers distributed in class.

BM 5023   Biomedical devices

"This course will cover the various biomedical devices and diagnostics in health care.

Syllabus :- Electrochemical devices for biosensing: blood glucose monitoring: Principle and working, cholesterol sensing, microfluidic devices, and Lab on a chip. (lectures + Lab); Blood pressure monitoring, Audiometry, Optical Pulse oximetry. ( lectures+ Lab); Electromyography principle, ECG and holter monitor devices, Arrythmia and Defibrillation and telemetry systems for health care ( lectures + Lab); Therapeutic instrumentation such as pacemakers, defibrillators and prosthetic devices will be reviewed.
References        
1.  Optics and Optical Instruments, B. K Johnson, Dover Books, 1960 III Ed.
2. Fundementals of Photonics B. E A. Saleh  and M. C. Teich John Wiley 2009.
3. Medical Instrumentation Application and Design, John Webster Ed. John Wiley & Sons 2009.
4. Additional materials distributed in class.

BM 6090    Biomedical imaging

Syllabus :- Medical imaging systems: Ultrasound, Photoacoustic imaging, MRI, X rays and CT; Nuclear imaging techniques: PET, SPECT, Optical imaging and microscopy, Molecular and Cellular imaging, Contrast agents (6 Lectures + Lab).
References
1.  Optics and Optical Instruments, B. K Johnson, Dover Books, 1960 III Ed.
2. Fundementals of Photonics B. E A. Saleh  and M. C. Teich John Wiley 2009.
3. Medical Instrumentation Application and Design, John Webster Ed. John Wiley & Sons 2009.
4. "Additional materials distributed in class".

BM 6123    Advances in Molecular Imaging

This course is intended to cover special imaging modalities like PET-CT, MRI, CT and MOLECULAR IMAGING. In this course, training will be given to the students in understanding the latest diagnostic modalities and state of art clinical imaging applications. Practical aspects in Clinical Radiology, Radiation Physics and working of instrumentation would be addressed as a part of this course by allowing the students to visit and attend hospital sessions. This will be useful for the students to understand the basic working principles of machines so that in future to develop/transform new applications for better use to the patients.
References      
1. Medical Instrumentation Application and Design, John Webster Ed. John Wiley & Sons 2009.
2. Additional materials distributed in class.

BM 6136    Clinical Health care

"Positive patient experience is a key aspect of designing medical products. Does this product ensure patient safety? Does this medical instrument make the patient feel more comfortable using it? Does this machine reduce error and increase accuracy, thereby increasing patients’ trust and psychological well-being? Questions such as these are asked not only by end-users, but also by science and engineering. Considering human factors, i.e. human interaction with systems, is quickly gaining importance where technology is increasingly user-centered. This course will first introduce psychology, highlight the role psychology plays in health both from a patient and doctor perspective, elaborate on human factors in medical device design, and how one tests for usability. Following this, students will visit some hospitals and observe patient experiences and interactions with medical devices. They will also interact with physicians to better understand their perspectives. A short report is required to be submitted as a course evaluation, which is aimed to encourage students to think innovatively about biomedical engineering and psychology.
References         
1) Marks, D.F., Murray, M., Evans, B., Willig, C., Woodall, C., & Sykes, C.M. (2008). Health Psychology: Theory, Research And Practice (2nded). New Delhi: Sage South Asia.
2) Weigner, M.E., Wiklund, M.E., & Gardner-bonneau, D.J. (2010). Handbook of Human Factors in Medical Device Design. USA: Crc Press.
3) Wiklund, M.E., Kendler, J., &Strochlic, A.Y. (2010). Usability testing of Medical Devices. USA: Crc Press.               

BM 6146    Clinical Immersion

Students will visit some hospitals and observe patient experiences and interactions with medical devices. They will also interact with physicians to better understand their perspectives. A short report is required to be submitted as a course evaluation, which is aimed to encourage students to think innovatively about biomedical engineering.
References
1. Zenos, Makover, P. Yock, Biodesign, Cambridge University Press (2009).
2. resources distributed in class.

BM 6110    Nanomedicine

This is a highly interdisciplinary course for graduate students (M. Tech, Ph. D) who are interested in learning about the emerging field of nanoscience and nanotechnology and its application in biology and medicine. To capture the excitement of this emerging field, in this coruse student will be familiarized with fundamentals of nanoscience and Nano-scale engineering, and their potential application in the human health care system. This course will emphasize emerging nanotechnologies and its biomedical applications including fundamental of nanomaterials and nanoengineering, notoxicology, nanotechnology for drug delivery, regenerative medicine, imaging, and diagnostic system and translating nano-medicines into clinical investigation.
References
1. Jain, Kewal K. The Handbook of Nanomedicine. Humana Press, 2008. ISBN-13: 978-1-6032-7318-3.
2. Nanomedicine Design of Particles, Sensors, Motors, Implants, Robots, and Devices. Ed. Mark J. Schulz, Vesselin N. Shanov, and Yeoheung Yun. Artech House, 2009. ISBN-13: 978-1-5969-3279-1.
3. Nanotechnology: Volume 5: Nanomedicine. Ed. Viola Vogel. Weinheim: Wiley-VCH Verlag GmbH & Co. KGaA, 2009. ISBN-13: 978-3-5273-1736-3.
4. Nanotechnology in Biology and Medicine: Methods, devices, and applications. Ed. Tuan Vo-Dinh. Boca Raton, FL: CRC Press, Taylor & Francis Group, 2007. ISBN-13: 978-0-8493-2949-4.
5.Tibbals, Harry F. Perspectives in Nanotechnology: Medical Nanotechnology and Nanomedicine. Ed. Gabor L. Hornyak. Boca Raton, FL: CRC Press, Taylor & Francis Group, 2011. ISBN-13: 978-1-4398-0874-0.
6.Vladimir P.Torchilin, Nanoparticulates as Drug Carriers, Imperial College Press, North Eastern, University, USA (2006).
7. David E Reisner, Bionanotechnology, Global Preospects, CRC press (2008).

BM 5090    Biomaterials: Materials in Medicine

This course is for PhD and M. Tech students. The primary objective of this course is to teach the fundamental properties of different type of materials and their use in the human body. Student will learn the different material properties necessary for the use in biomedical application of the verities of materials. This course will help student to design a novel biomaterial for the specific application.
References
1. Biomaterials Science - Ratner, Hoffman, Schoen, Lemons (Elsevier; ISBN 0-12-582461)Biomaterials - Temenoff and Mikos (Pearson Prentice Hall; ISBN 0-13-009710-1).
2. Materials Science and Engineering: An Introduction - Callister (John Wiley and Sons; ISBN 0-
471-13576-3).

BM5141    Advanced Biomaterials

This course is a laboratory based practical course for PhD and M.Tech students where student will prepare biomaterials for tissue engineering and drug delivery. In this course we will emphasize on the preparation of different type of scaffold and nanocarrier for tissue engineering and drug delivery application respectively. Students also learn the physical and biological characterization technique of these biomaterials. The biological characterization techniques include stem cells/cells base evaluation of these biomaterials.
References
1. Biomaterials Science - Ratner, Hoffman, Schoen, Lemons (Elsevier; ISBN 0-12-582461) Biomaterials - Temenoff and Mikos (Pearson Prentice Hall; ISBN 0-13-009710-1).
2. Relevent journal publications.
               

BM 5110   Lab on Chip

Syllabus :- Introduction to Micro Nano scale phenomena – Biochips and Microfluidic Technology – Analogy with electrical circuits – Simple modeling designs – Electrokinetic manipulation of cells and macromolecules (Proteins/DNA) – Introduction to Micro Nano fabrication - Applications of Immunoassay On Chip – Outline and overview of Single cell Nanobiology on Chip.
References      
1. Introduction to Microfluidics - Patrick Tabeling, Oxford University Press (978-0-19-958816-9).
2. Relevant e-books and journal publications.

BM 6070    Biomicrofluidics

Syllabus :- Introduction to Micro Nano scale fluid flows and Mass transport – Navier Stokes equation, Convection Diffusion equation and analytical solutions for flows in rectangular channel cross sections – Flow field fractionation using Dielectrophoresis – Separaion and concentration of Cells on Chip using Acoustic, Magnetic and Optical fields – Microfabrication – materials - thin film deposition and patterning techniques – Bonding techniques – 3D/Multilayer fabrication of microfluidic Chips – Applications – Drug screening - SERS on Chip using magnetic nanoparticles – Single Cell trapping techniques on Chip – Stem Cell differentiation studies on Chip – Microfluidic PCR - Biochips for studies on Protein Folding.
References        
1. Introduction to Microfluidics - Patrick Tabeling, Oxford University Press (978-0-19-958816-9).
2. Relevant e-books and journal publications.

BM 5040    Biomechanics

Syllabus :- Introduction to concept of stress/strain and elasticity - Normal and Shear stress - Linear models - Isotropic and Anisotropic materials - Matrix formulation to solve problems of elasticity - Biomechanics of body joints (knee and ankle) - Soft tissue mechanics and Introduction to non - linear models.
References        
1. An Introduction to Biomechanics - Solids, Fluids and Design, Jay.D.Humphrey and Sherry.L.Delange, Springer Science (ISBN: 978-1-4899-0325-9).
2. Relevant e-books and journal publications.

BM 6080   Advanced Biomechanics

Syllabus :- Isotropic and Anisotropic models of elasticity - Non linear models for soft tissue mechanics - Biofluid mechanics - Newtonian and Non-Newtonian fluids -Effect of constituents of blood and synovial fluid on viscosity - Navier Stokes equation and analytical solutions for flows in different geometries - Non-Newtonian flow modeling - Arteial Blood flow - Pulsatile flows in arteries and analytical solutions for transient velocity field and shear stress - Oscillatory wall shear stress and its significance - modeling of Spherical Aneurysms.
References        
1. An Introduction to Biomechanics - Solids, Fluids and Design, Jay.D.Humphrey and Sherry.L.Delange, Springer Science (ISBN: 978-1-4899-0325-9).
2. Relevant e-books and journal publications.

Department of Biomedical Engineering, Indian Institute of Technology Hyderabad, Ordnance Factory Estate, Yeddumailaram - 502 205,
Andhra Pradesh, INDIA. Tel : +91 (40) 2301 6097