


M.Tech (2year) Course Curriculum BM 5030 Scientific Computing and data analysis The course intends to introduce the students of first year interdisciplinary masters programs to scientific computing and tools for the same. This course will be compulsory for students with basic degree in Life sciences and others not exposed to quantitative sciences. The main contents of the course are : Matrices, matrix operations, factorisations, eigen values, transforms, Linear equations; Coding in MATLAB and Python using matrices as elementary structures; Probability and random variables;statistical hypothesis testing. BM 6150 Mathematical Physiology and Modeling This course for senior undergraduates and postgraduates will introduce the principles of physiology and its mathematical characterisation. The course will cover the important elements of physiology like Cellular function, Growth, Homoeostasis and metab , Characterisation of some systems
e.g. Cardiovascular, Respiratory, Endocrine BM 5050 Introduction to Brain and Neuroscience This course is an undergraduate's introduction to the fascinating world of the brain and its study. The course will give an overview of the structure and function of the brain along with the nervous system using interesting case studies and descriptions of experiments. Students will be introduced to various disciplines that go under the umbrella term of neurosciences like Cognitive, behavioral, network, cellular, developmental or computational neurosciences. The course will emphasize on the interdisciplinary nature of modern neuroscience and opportunities for people from various backgrounds to contribute to it. Towards the end of the course students pick a landmark paper or case study and present the same in class. Syllabus : Introduction  Organization of the brain and its function; Behaviour and cognition; Systems : Motor, sensory and learning; Regions; Networks; Neuron; Ion channels; Neural development and disease; Role of experiments and computation in neuroscience; Methods in neuroscience; The interdisciplinary nature of neuroscience References BM 6140 Theoretical and Computational Neuroscience: From cell to systems This course is a first pass through the principles of working of the brain from the level of a single neuron to systems and behaviour. The course focuses on characterising the operating principles of the brain at various levels and the mathematical models used to represent them. The objective of the course is to develop in students an ability to convert concepts in neurophysiology into a mathematical model. Syllabus : Genesis of electrical activity in cells, resting membrane potentials; Neuron equivalent circuits and passive propagation in neurons; HodgkinHuxley equations and conductance based models; Ion channels and their diversity; Simple neuron models and analysis using dynamical systems concepts; Chemical and electrical synapses and their models; Neuronal networks and techniques for mathematical analysis; Models of learning and memory in the neuron and the network; Models of cognition, decision making and psychophysical models; Systems (sensory and motor systems) and their modeling; Neural coding (Rate, temporal, population); Neuronal data analysis techniques (Preprocessing, Spike detection and sorting techniques). BM 5060 Cellular Physiology This course is intended for basic understanding of cell physiology in the engineers’ perspective. The students need to understand the cellular structure and physiological functions. Syllabus : Cell structure and its organelles; Cell membrane; Cell homeostasis; Nucleus structure and function of its different components. BM 5070 Systems Physiology This course is intended for basic understanding of human physiology in the engineers’ perspective. The students need to understand different physiological systems; and their dysfunction by applying engineering and mathematics knowledge. The important systems which may be covered are respiratory, renal, endocrine, gastrointestinal tract, cutaneous, and other relvant systems. Syllabus : Respiratory: anatomy, gas exchange, acidbase balance; Renal: anatomy, ion exchange, transport of metabolites; Gastrointestinal tract: anatomy, absorption of micronutrients, dysfunction; Cutaneous system: anatomy, temperature regulation;
Endocrine: basic function, major endocrine organs and their regulation, bone physiology; BM 6023 Cell technology This course is intended for practical handling experience for students for culture of mammalian cells. They should learn detailed stepwise protocols in culturing, freezing, splitting of mammalian cells. They should also learn basic molecular biology methods such as DNA, RNA isolation from cultured cells and running a polymerase chain reaction. BM 6120 Tissue Engineering The students will learn how to test the biomaterials along with a number of cell types in vitro and in vivo. He should learn how the physiological cues are combined together with biomaterials for regenerative medicine point of view. Syllabus : Tissue engineering: fundamentals and current status; Stem cells: embryonic and mesenchymal stem cells; cell differentiation; Extracellular matrix components and their regulation of cell behavior; In vitro and in vivo testing of biomaterials. Bioreactor; Cell migration; Growth factors; Different approaches for angiogenesis and its importance. BM 6126 Regenerative Medicine The students will learn in a seminarbased manner about a number of tissuespecific regenerative medicine and various approaches to achieve this. BM 5013 Sensors and Transducers in Health care This course is intended to understand the origin of signals in biosystems and living organisms, their sensing, detection and meaningful processing for practical diagnostic sensing applications. Various engineering aspects of the detection, acquisition, processing, and display of signals, biomedical sensors for measurements of biopotentials, ECG, force, displacement, blood pressure and temperature sensors, will be addressed in this course. The course includes work involving circuits, electronics, sensor design and interfaces for building complete biomedical instrumentation. Syllabus : BM 5023 Biomedical devices "This course will cover the various biomedical devices and diagnostics in health care. Syllabus : Electrochemical devices for biosensing: blood glucose monitoring: Principle and working, cholesterol sensing, microfluidic devices, and Lab on a chip. (lectures + Lab);
Blood pressure monitoring, Audiometry, Optical Pulse oximetry. ( lectures+ Lab);
Electromyography principle, ECG and holter monitor devices, Arrythmia and Defibrillation and telemetry systems for health care ( lectures + Lab); Therapeutic instrumentation such as pacemakers, defibrillators and prosthetic devices will be reviewed. BM 6090 Biomedical imaging Syllabus : Medical imaging systems: Ultrasound, Photoacoustic imaging, MRI, X rays and CT; Nuclear imaging techniques: PET, SPECT, Optical imaging and microscopy, Molecular and Cellular imaging, Contrast agents (6 Lectures + Lab). BM 6123 Advances in Molecular Imaging This course is intended to cover special imaging modalities like PETCT, MRI, CT and MOLECULAR IMAGING. In this course, training will be given to the students in understanding the latest diagnostic modalities and state of art clinical imaging applications. Practical aspects in Clinical Radiology, Radiation Physics and working of instrumentation would be addressed as a part of this course by allowing the students to visit and attend hospital sessions. This will be useful for the students to understand the basic working principles of machines so that in future to develop/transform new applications for better use to the patients. BM 6136 Clinical Health care "Positive patient experience is a key aspect of designing medical products. Does this product ensure patient safety? Does this medical instrument make the patient feel more comfortable using it? Does this machine reduce error and increase accuracy, thereby increasing patients’ trust and psychological wellbeing? Questions such as these are asked not only by endusers, but also by science and engineering. Considering human factors, i.e. human interaction with systems, is quickly gaining importance where technology is increasingly usercentered. This course will first introduce psychology, highlight the role psychology plays in health both from a patient and doctor perspective, elaborate on human factors in medical device design, and how one tests for usability. Following this, students will visit some hospitals and observe patient experiences and interactions with medical devices. They will also interact with physicians to better understand their perspectives. A short report is required to be submitted as a course evaluation, which is aimed to encourage students to think innovatively about biomedical engineering and psychology. BM 6146 Clinical Immersion Students will visit some hospitals and observe patient experiences and interactions with medical devices. They will also interact with physicians to better understand their perspectives. A short report is required to be submitted as a course evaluation, which is aimed to encourage students to think innovatively about biomedical engineering. BM 6110 Nanomedicine This is a highly interdisciplinary course for graduate students (M. Tech, Ph. D) who are interested in learning about the emerging field of nanoscience and nanotechnology and its application in biology and medicine. To capture the excitement of this emerging field, in this coruse student will be familiarized with fundamentals of nanoscience and Nanoscale engineering, and their potential application in the human health care system. This course will emphasize emerging nanotechnologies and its biomedical applications including fundamental of nanomaterials and nanoengineering, notoxicology, nanotechnology for drug delivery, regenerative medicine, imaging, and diagnostic system and translating nanomedicines into clinical investigation. BM 5090 Biomaterials: Materials in Medicine This course is for PhD and M. Tech students. The primary objective of this course is to teach the fundamental properties of different type of materials and their use in the human body. Student will learn the different material properties necessary for the use in biomedical application of the verities of materials. This course will help student to design a novel biomaterial for the specific application. BM5141 Advanced Biomaterials This course is a laboratory based practical course for PhD and M.Tech students where student will prepare biomaterials for tissue engineering and drug delivery. In this course we will emphasize on the preparation of different type of scaffold and nanocarrier for tissue engineering and drug delivery application respectively. Students also learn the physical and biological characterization technique of these biomaterials. The biological characterization techniques include stem cells/cells base evaluation of these biomaterials. BM 5110 Lab on Chip Syllabus : Introduction to Micro Nano scale phenomena – Biochips and Microfluidic Technology – Analogy with electrical circuits – Simple modeling designs – Electrokinetic manipulation of cells and macromolecules (Proteins/DNA) – Introduction to Micro Nano fabrication  Applications of Immunoassay On Chip – Outline and overview of Single cell Nanobiology on Chip. BM 6070 Biomicrofluidics Syllabus : Introduction to Micro Nano scale fluid flows and Mass transport – Navier Stokes equation, Convection Diffusion equation and analytical solutions for flows in rectangular channel cross sections – Flow field fractionation using Dielectrophoresis – Separaion and concentration of Cells on Chip using Acoustic, Magnetic and Optical fields – Microfabrication – materials  thin film deposition and patterning techniques – Bonding techniques – 3D/Multilayer fabrication of microfluidic Chips – Applications – Drug screening  SERS on Chip using magnetic nanoparticles – Single Cell trapping techniques on Chip – Stem Cell differentiation studies on Chip – Microfluidic PCR  Biochips for studies on Protein Folding. BM 5040 Biomechanics Syllabus : Introduction to concept of stress/strain and elasticity  Normal and Shear stress  Linear models  Isotropic and Anisotropic materials  Matrix formulation to solve problems of elasticity  Biomechanics of body joints (knee and ankle)  Soft tissue mechanics and Introduction to non  linear models. BM 6080 Advanced Biomechanics Syllabus : Isotropic and Anisotropic models of elasticity  Non linear models for soft tissue mechanics  Biofluid mechanics  Newtonian and NonNewtonian fluids Effect of constituents of blood and synovial fluid on viscosity  Navier Stokes equation and analytical solutions for flows in different geometries  NonNewtonian flow modeling  Arteial Blood flow  Pulsatile flows in arteries and analytical solutions for transient velocity field and shear stress  Oscillatory wall shear stress and its significance  modeling of Spherical Aneurysms. 